Composition control of microbial communities

Microbial communities in nature often function as consortia, where different populations cooperate and divide labor to enhance efficiency and survival. However, engineering such consortia requires mechanisms to ensure long-term coexistence and proper function of the consortium. To achieve this goal, I investigated strategies to regulate the relative abundance of each population - a concept known as composition or ratiometric control.

Related Publications

• Brancato, S. M., Salzano, D., Fiore, D., Russo, G., & Di Bernardo, M. (2024). Ratiometric control of two microbial populations via a dual chamber bioreactor. IEEE Control Systems Letters, 8, 1301-1306.
• Brancato, S. M., Salzano, D., De Lellis, F., Fiore, D., Russo, G., & di Bernardo, M. (2024, June). In vivo learning-based control of microbial populations density in bioreactors. In 6th Annual Learning for Dynamics & Control Conference (pp. 941-953). PMLR.
• Fusco, V., Salzano, D., Fiore, D., & di Bernardo, M. (2023). Embedded control of cell growth using tunable genetic systems. International Journal of Robust and Nonlinear Control, 33(9), 4893-4907.
• Karagiannis-Axypolitidis, N., Salzano, D., Fiore, D., Cartenì, F., Mazzoleni, S., Di Bernardo, M., & Giannino, F. (2023, June). A periodic open-loop strategy to mitigate plant-soil negative feedback. In 2023 European Control Conference (ECC) (pp. 1-6). IEEE.
• Salzano, D., Fiore, D., & di Bernardo, M. (2022). Ratiometric control of cell phenotypes in monostrain microbial consortia. Journal of the Royal Society Interface, 19(192), 20220335.
• Salzano, D., Fiore, D., & di Bernardo, M. (2019, December). Ratiometric control for differentiation of cell populations endowed with synthetic toggle switches. In 2019 IEEE 58th Conference on Decision and Control (CDC) (pp. 927-932). IEEE.