Composition control of microbial communities

Strategies to regulate relative abundances and enable stable coexistence in engineered consortia.

Ratiometric control Bioreactors Synthetic biology

Composition control of microbial communities

Microbial consortia can divide labor and achieve functionalities that single strains cannot. Engineering such systems requires methods to keep multiple strains coexisting and performing desired tasks. My work investigates ratiometric control strategies and experimental platforms (e.g., dual-chamber bioreactors) to regulate and stabilise community composition over time.

Related Publications

Campanile, G., Martinelli, V., Salzano, D., & Fiore, D.
Regulating population density through antithetic feedback control of cell growth. IFAC Journal of Systems and Control, Volume 35, 100386, 2026.
Brancato, S. M., Salzano, D., Fiore, D., Russo, G., & Di Bernardo, M.
Ratiometric control of two microbial populations via a dual chamber bioreactor. IEEE Control Systems Letters, 8, 1301-1306 (2024).
Brancato, S. M., Salzano, D., De Lellis, F., Fiore, D., Russo, G., & di Bernardo, M.
In vivo learning-based control of microbial populations density in bioreactors. Learning for Dynamics & Control (L4DC) (2024).
Fusco, V., Salzano, D., Fiore, D., & di Bernardo, M.
Embedded control of cell growth using tunable genetic systems. Int. Journal of Robust and Nonlinear Control, 33(9), 4893-4907 (2023).
Karagiannis-Axypolitidis, N., Salzano, D., Fiore, D., Cartenì, F., Mazzoleni, S., Di Bernardo, M., & Giannino, F.
A periodic open-loop strategy to mitigate plant-soil negative feedback. European Control Conference (ECC), 2023.
Salzano, D., Fiore, D., & di Bernardo, M.
Ratiometric control of cell phenotypes in monostrain microbial consortia. Journal of the Royal Society Interface, 19(192), 20220335 (2022).
Salzano, D., Fiore, D., & di Bernardo, M.
Ratiometric control for differentiation of cell populations endowed with synthetic toggle switches. 2019 IEEE 58th Conference on Decision and Control (CDC).